Attenuated endothelin‐1 (ET‐1) vasoconstrictor responses in cardiometabolic syndrome are attributed to increased ET‐B receptors
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منابع مشابه
Cutaneous vasoconstrictor responses to norepinephrine are attenuated in older humans.
Cutaneous vasoconstriction (VC) in response to cooling is impaired with human aging. On the basis of previous findings that older humans rely predominantly on norepinephrine (NE) for reflex VC of skin blood vessels, and that the VC effects of NE are blunted with age in many vascular beds, we tested the hypothesis that cutaneous VC responses to exogenous NE are attenuated in aged skin compared w...
متن کاملReactive oxygen species participate in acute renal vasoconstrictor responses induced by ETA and ETB receptors.
Reactive oxygen species (ROS) play important roles in renal vasoconstrictor responses to acute and chronic stimulation by angiotensin II and norepinephrine, as well as in long-term effects of endothelin-1 (ET-1). Little is known about participation of ROS in acute vasoconstriction produced by ET-1. We tested the influence of NAD(P)H oxidase inhibition by apocynin [4 mg.kg(-1).min(-1), infused i...
متن کاملVasoconstrictor effect of endothelin-1 in human skin: role of ETA and ETB receptors.
The aim of this project was to investigate the role of ETA and ETB receptors in the mediation of endothelin (ET)-1-induced vasoconstriction in human skin. This information should provide important insights into the design of pharmacological intervention against skin vasospasm induced by ET-1 in peripheral vascular disease or surgical trauma. Vasoconstriction in response to intra-arterial drug i...
متن کاملETA and ETB receptors are expressed in vascular adventitial fibroblasts.
The adventitia has been recognized to play important roles in vascular oxidative stress, remodeling, and contraction. We recently demonstrated that adventitial fibroblasts are able to express endothelin (ET)-1 in response to ANG II. However, it is unclear whether ET-1 receptors are expressed in the adventitia. We therefore investigated the expression and roles of both ET(A) and ET(B) receptors ...
متن کاملCALL FOR PAPERS Physiology and Pharmacology of Temperature Regulation Cutaneous vasoconstrictor responses to norepinephrine are attenuated in older humans
Thompson, Caitlin S., Lacy A. Holowatz, and W. Larry Kenney. Cutaneous vasoconstrictor responses to norepinephrine are attenuated in older humans. Am J Physiol Regul Integr Comp Physiol 288: R1108 –R1113, 2005. First published January 20, 2005; doi:10.1152/ajpregu.00839.2004.—Cutaneous vasoconstriction (VC) in response to cooling is impaired with human aging. On the basis of previous findings t...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.978.10